Choline Acetyltransferase anticorps

N° du produit ABIN361419

Cet anticorps anti-Choline Acetyltransferase est un anticorps Chèvre Polyclonal détectant Choline Acetyltransferase dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour Choline Acetyltransferase anticorps (ABIN361419)

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Choline Acetyltransferase est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Choline Acetyltransferase anticorps

Specificité: Specific for the ~ 70k choline acetyltransferase protein

Réactivité croisée: Oiseau, Poulet, Cobaye, Humain, Souris, Non-Human Primate

Purification: Affinity Purified

Immunogène: Native choline acetyltransferase purifed from human placenta

Information d'application

Indications d'application: Recommended Dilution: WB: 1:100 IHC: 1:100 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur Choline Acetyltransferase

Antigène: Choline Acetyltransferase (CHAT) (Choline O-Acetyltransferase (CHAT))

Autre désignation: CHAT

Sujet: Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999). Anti-Choline Acetyltransferase Western blot of rat brain lysate showing specific immunolabeling of the ~70k ChAT

Poids moléculaire: '70 kDa

ID gène: 1103

Pathways: Skeletal Muscle Fiber Development